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<p dir="ltr" style="line-height: 1.38; margin-top: 12pt; margin-bottom: 12pt;">[size= 11pt; font-family: Arial,sans-serif; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap]Persistent sleep problems can have many causes. Stress, irregular sleep schedules, caffeine, alcohol, medications, medical conditions, mental health conditions, and other sleep disorders can contribute to insomnia. For that reason, treatment may involve identifying and addressing the underlying cause rather than relying exclusively on medication.[/size]

<h1 dir="ltr" style="line-height: 1.38; margin-top: 24pt; margin-bottom: 6pt;">[size= 23pt; font-family: Arial,sans-serif; color: #000000; background-color: transparent; font-weight: bold; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap]How to Take Zolpidem Safely[/size]</h1>
<p dir="ltr" style="line-height: 1.38; margin-top: 12pt; margin-bottom: 12pt;">[size= 11pt; font-family: Arial,sans-serif; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap]Zolpidem should be taken exactly according to the prescription label. For standard tablets and certain other formulations, it is generally taken immediately before bedtime when the patient has enough time available for a full night's sleep. MedlinePlus advises patients taking standard tablets, extended-release tablets, sublingual tablets such as Edluar, or oral spray to plan for approximately [/size][size= 11pt; font-family: Arial,sans-serif; color: #000000; background-color: transparent; font-weight: bold; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap]7 to 8 hours in bed[/size][size= 11pt; font-family: Arial,sans-serif; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap] after taking the medicine.[/size]

<p dir="ltr" style="line-height: 1.38; margin-top: 12pt; margin-bottom: 12pt;">[size= 11pt; font-family: Arial,sans-serif; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap]Taking zolpidem when there is not enough time remaining to sleep can increase the likelihood of next-day drowsiness and impairment. Patients should not take more than the prescribed amount or use another sleeping pill during the same night unless specifically directed by a healthcare professional.[/size]

<p dir="ltr" style="line-height: 1.38; margin-top: 12pt; margin-bottom: 12pt;">[size= 11pt; font-family: Arial,sans-serif; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap]Extended-release tablets should generally be swallowed whole. Crushing, chewing, or splitting a formulation intended to be swallowed whole can interfere with its release characteristics.[/size]

<h1 dir="ltr" style="line-height: 1.38; margin-top: 24pt; margin-bottom: 6pt;">[size= 23pt; font-family: Arial,sans-serif; color: #000000; background-color: transparent; font-weight: bold; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap]Food and Timing[/size]</h1>
<p dir="ltr" style="line-height: 1.38; margin-top: 12pt; margin-bottom: 12pt;">[size= 11pt; font-family: Arial,sans-serif; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap]Zolpidem may act more slowly when taken with or immediately after a meal. Patients should follow the specific instructions supplied with their formulation. Taking the medicine at the wrong time can affect how quickly it begins to work and may increase the chance that the person will not have enough time remaining for adequate sleep.[/size]

<p dir="ltr" style="line-height: 1.38; margin-top: 12pt; margin-bottom: 12pt;">[size= 11pt; font-family: Arial,sans-serif; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap]If a patient is unsure about when to take the medicine, the pharmacist or prescriber should be consulted rather than changing the schedule independently.[/size]

<h1 dir="ltr" style="line-height: 1.38; margin-top: 24pt; margin-bottom: 6pt;">[size= 23pt; font-family: Arial,sans-serif; color: #000000; background-color: transparent; font-weight: bold; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap]Common Side Effects[/size]</h1>
<p dir="ltr" style="line-height: 1.38; margin-top: 12pt; margin-bottom: 12pt;">[size= 11pt; font-family: Arial,sans-serif; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap]Zolpidem can cause side effects, although not everyone experiences them. Possible effects include:[/size]

<ul style="margin-top: 0; margin-bottom: 0; padding-inline-start: 48px;">
<li dir="ltr" style="list-style-type: disc; font-size: 11pt; font-family: Arial,sans-serif; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre;">
<p dir="ltr" style="line-height: 1.38; margin-top: 12pt; margin-bottom: 0pt;">[size= 11pt; font-family: Arial,sans-serif; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap]Drowsiness[/size]

</li>
<li dir="ltr" style="list-style-type: disc; font-size: 11pt; font-family: Arial,sans-serif; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre;">
<p dir="ltr" style="line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;">[size= 11pt; font-family: Arial,sans-serif; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap]Dizziness[/size]

</li>
<li dir="ltr" style="list-style-type: disc; font-size: 11pt; font-family: Arial,sans-serif; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre;">
<p dir="ltr" style="line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;">[size= 11pt; font-family: Arial,sans-serif; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap]Headache[/size]

</li>
<li dir="ltr" style="list-style-type: disc; font-size: 11pt; font-family: Arial,sans-serif; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre;">
<p dir="ltr" style="line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;">[size= 11pt; font-family: Arial,sans-serif; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap]Fatigue[/size]

</li>
<li dir="ltr" style="list-style-type: disc; font-size: 11pt; font-family: Arial,sans-serif; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre;">
<p dir="ltr" style="line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;">[size= 11pt; font-family: Arial,sans-serif; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap]Lightheadedness[/size]

</li>
<li dir="ltr" style="list-style-type: disc; font-size: 11pt; font-family: Arial,sans-serif; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre;">
<p dir="ltr" style="line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;">[size= 11pt; font-family: Arial,sans-serif; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap]Unsteady walking[/size]

</li>
<li dir="ltr" style="list-style-type: disc; font-size: 11pt; font-family: Arial,sans-serif; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre;">
<p dir="ltr" style="line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;">[size= 11pt; font-family: Arial,sans-serif; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap]Problems with balance[/size]

</li>
<li dir="ltr" style="list-style-type: disc; font-size: 11pt; font-family: Arial,sans-serif; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre;">
<p dir="ltr" style="line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;">[size= 11pt; font-family: Arial,sans-serif; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap]Nausea[/size]

</li>
<li dir="ltr" style="list-style-type: disc; font-size: 11pt; font-family: Arial,sans-serif; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre;">
<p dir="ltr" style="line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;">[size= 11pt; font-family: Arial,sans-serif; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap]Drugged or slowed feeling[/size]

</li>
<li dir="ltr" style="list-style-type: disc; font-size: 11pt; font-family: Arial,sans-serif; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre;">
<p dir="ltr" style="line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;">[size= 11pt; font-family: Arial,sans-serif; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap]Memory or concentration difficulties[/size]

</li>
<li dir="ltr" style="list-style-type: disc; font-size: 11pt; font-family: Arial,sans-serif; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre;">
<p dir="ltr" style="line-height: 1.38; margin-top: 0pt; margin-bottom: 12pt;">[size= 11pt; font-family: Arial,sans-serif; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap]Unusual dreams[/size]

</li>
</ul>
<p dir="ltr" style="line-height: 1.38; margin-top: 12pt; margin-bottom: 12pt;">[size= 11pt; font-family: Arial,sans-serif; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap]Some people may experience impairment the next morning. FDA information specifically warns that insomnia medicines, including zolpidem, can affect activities requiring alertness even when a person believes they are fully awake.[/size]

<p dir="ltr" style="line-height: 1.38; margin-top: 12pt; margin-bottom: 12pt;">[size= 11pt; font-family: Arial,sans-serif; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap]Patients should understand their individual response before driving, operating machinery, or performing other activities that require complete attention.[/size]

<h1 dir="ltr" style="line-height: 1.38; margin-top: 24pt; margin-bottom: 6pt;">[size= 23pt; font-family: Arial,sans-serif; color: #000000; background-color: transparent; font-weight: bold; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap]Serious Warnings About Complex Sleep Behaviors[/size]</h1>
<p dir="ltr" style="line-height: 1.38; margin-top: 12pt; margin-bottom: 12pt;">[size= 11pt; font-family: Arial,sans-serif; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap]One of the most significant safety concerns associated with zolpidem is [/size][size= 11pt; font-family: Arial,sans-serif; color: #000000; background-color: transparent; font-weight: bold; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap]complex sleep behavior[/size][size= 11pt; font-family: Arial,sans-serif; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap]. A person may get out of bed while not fully awake and perform activities such as walking, eating, making phone calls, or driving. They may have little or no memory of what happened afterward.[/size]

<p dir="ltr" style="line-height: 1.38; margin-top: 12pt; margin-bottom: 12pt;">[size= 11pt; font-family: Arial,sans-serif; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap]The FDA added a boxed warning to certain prescription insomnia medicines because these behaviors have resulted in serious injuries and, in rare cases, deaths. Complex sleep behaviors can occur even after the first dose and are not limited to high doses.[/size]

<p dir="ltr" style="line-height: 1.38; margin-top: 12pt; margin-bottom: 12pt;">[size= 11pt; font-family: Arial,sans-serif; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap]If a patient experiences a complex sleep behavior while taking zolpidem, FDA guidance states that the medicine should be discontinued and the healthcare professional contacted immediately. Patients who have previously experienced such a reaction should tell their healthcare professional before using zolpidem again.[/size]

<h1 dir="ltr" style="line-height: 1.38; margin-top: 24pt; margin-bottom: 6pt;">[size= 23pt; font-family: Arial,sans-serif; color: #000000; background-color: transparent; font-weight: bold; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap]Next-Morning Impairment[/size]</h1>
<p dir="ltr" style="line-height: 1.38; margin-top: 12pt; margin-bottom: 12pt;">[size= 11pt; font-family: Arial,sans-serif; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap]Next-day impairment is different from complex sleep behavior. A person with next-morning impairment is awake but may still have enough zolpidem in the bloodstream to affect alertness, reaction time, coordination, or driving ability.[/size]

<p dir="ltr" style="line-height: 1.38; margin-top: 12pt; margin-bottom: 12pt;">[size= 11pt; font-family: Arial,sans-serif; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap]The risk can be influenced by dose, formulation, individual metabolism, and other factors. FDA has specifically addressed this concern with zolpidem and has emphasized lower dosing and careful consideration of patient-specific factors.[/size]

<p dir="ltr" style="line-height: 1.38; margin-top: 12pt; margin-bottom: 12pt;">[size= 11pt; font-family: Arial,sans-serif; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap]If someone feels sleepy, dizzy, confused, or impaired after taking zolpidem, they should not drive or perform hazardous activities.[/size]

<h1 dir="ltr" style="line-height: 1.38; margin-top: 24pt; margin-bottom: 6pt;">[size= 23pt; font-family: Arial,sans-serif; color: #000000; background-color: transparent; font-weight: bold; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap]Ambien and Alcohol[/size]</h1>
<p dir="ltr" style="line-height: 1.38; margin-top: 12pt; margin-bottom: 12pt;">[size= 11pt; font-family: Arial,sans-serif; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap]Alcohol can increase the sedative effects of zolpidem. Combining the two may increase impairment and other risks. FDA and MedlinePlus guidance advises avoiding alcohol while taking zolpidem.[/size]

<p dir="ltr" style="line-height: 1.38; margin-top: 12pt; margin-bottom: 12pt;">[size= 11pt; font-family: Arial,sans-serif; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap]Patients should also tell their healthcare professional about alcohol use because this information can affect the safety assessment and treatment plan.[/size]

<h1 dir="ltr" style="line-height: 1.38; margin-top: 24pt; margin-bottom: 6pt;">[size= 23pt; font-family: Arial,sans-serif; color: #000000; background-color: transparent; font-weight: bold; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap]Ambien and Other Medicines[/size]</h1>
<p dir="ltr" style="line-height: 1.38; margin-top: 12pt; margin-bottom: 12pt;">[size= 11pt; font-family: Arial,sans-serif; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap]Patients should provide a complete list of prescription medicines, over-the-counter products, vitamins, supplements, and herbal products before starting zolpidem. Some medicines can increase sedation or alter how zolpidem affects the body.[/size]

<p dir="ltr" style="line-height: 1.38; margin-top: 12pt; margin-bottom: 12pt;">[size= 11pt; font-family: Arial,sans-serif; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap]Particular caution may be necessary with other central nervous system depressants, including opioids, benzodiazepines, certain antihistamines, and other sleep medicines. Combining sedating medicines can increase impairment and may create additional safety concerns.[/size]

<p dir="ltr" style="line-height: 1.38; margin-top: 12pt; margin-bottom: 12pt;">[size= 11pt; font-family: Arial,sans-serif; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap]Patients should not take multiple sleeping pills on the same night unless a healthcare professional has specifically instructed them to do so.[/size]

<h1 dir="ltr" style="line-height: 1.38; margin-top: 24pt; margin-bottom: 6pt;">[size= 23pt; font-family: Arial,sans-serif; color: #000000; background-color: transparent; font-weight: bold; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap]Dependence, Misuse, and Withdrawal[/size]</h1>
<p dir="ltr" style="line-height: 1.38; margin-top: 12pt; margin-bottom: 12pt;">[size= 11pt; font-family: Arial,sans-serif; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap]Zolpidem can be habit-forming. The risk may increase when it is taken in larger amounts, more frequently, or for longer than prescribed. Patients should never share zolpidem with another person.[/size]

<p dir="ltr" style="line-height: 1.38; margin-top: 12pt; margin-bottom: 12pt;">[size= 11pt; font-family: Arial,sans-serif; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap]Stopping zolpidem suddenly after regular or prolonged use can produce withdrawal symptoms in some people. MedlinePlus describes possible symptoms including anxiety, shaking, nausea, sweating, mood changes, and worsening difficulty sleeping. Rarely, more serious withdrawal effects such as seizures can occur.[/size]

<p dir="ltr" style="line-height: 1.38; margin-top: 12pt; margin-bottom: 12pt;">[size= 11pt; font-family: Arial,sans-serif; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap]Patients who have been using zolpidem regularly should discuss discontinuation with their healthcare professional instead of stopping abruptly without guidance.[/size]

<h1 dir="ltr" style="line-height: 1.38; margin-top: 24pt; margin-bottom: 6pt;">[size= 23pt; font-family: Arial,sans-serif; color: #000000; background-color: transparent; font-weight: bold; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap]Who Should Discuss Extra Precautions With a Doctor?[/size]</h1>
<p dir="ltr" style="line-height: 1.38; margin-top: 12pt; margin-bottom: 12pt;">[size= 11pt; font-family: Arial,sans-serif; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap]Before taking zolpidem, patients should tell their healthcare professional if they have:[/size]

<ul style="margin-top: 0; margin-bottom: 0; padding-inline-start: 48px;">
<li dir="ltr" style="list-style-type: disc; font-size: 11pt; font-family: Arial,sans-serif; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre;">
<p dir="ltr" style="line-height: 1.38; margin-top: 12pt; margin-bottom: 0pt;">[size= 11pt; font-family: Arial,sans-serif; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap]Sleep apnea or other breathing problems[/size]

</li>
<li dir="ltr" style="list-style-type: disc; font-size: 11pt; font-family: Arial,sans-serif; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre;">
<p dir="ltr" style="line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;">[size= 11pt; font-family: Arial,sans-serif; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap]Liver or kidney disease[/size]

</li>
<li dir="ltr" style="list-style-type: disc; font-size: 11pt; font-family: Arial,sans-serif; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre;">
<p dir="ltr" style="line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;">[size= 11pt; font-family: Arial,sans-serif; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap]A history of substance misuse[/size]

</li>
<li dir="ltr" style="list-style-type: disc; font-size: 11pt; font-family: Arial,sans-serif; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre;">
<p dir="ltr" style="line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;">[size= 11pt; font-family: Arial,sans-serif; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap]Depression or other mental health conditions[/size]

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<li dir="ltr" style="list-style-type: disc; font-size: 11pt; font-family: Arial,sans-serif; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre;">
<p dir="ltr" style="line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;">[size= 11pt; font-family: Arial,sans-serif; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap]Heavy snoring or suspected sleep-disordered breathing[/size]

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<li dir="ltr" style="list-style-type: disc; font-size: 11pt; font-family: Arial,sans-serif; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre;">
<p dir="ltr" style="line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;">[size= 11pt; font-family: Arial,sans-serif; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap]Previous unusual sleep behaviors[/size]

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<li dir="ltr" style="list-style-type: disc; font-size: 11pt; font-family: Arial,sans-serif; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre;">
<p dir="ltr" style="line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;">[size= 11pt; font-family: Arial,sans-serif; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap]A history of medication reactions[/size]

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<li dir="ltr" style="list-style-type: disc; font-size: 11pt; font-family: Arial,sans-serif; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre;">
<p dir="ltr" style="line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;">[size= 11pt; font-family: Arial,sans-serif; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap]Pregnancy or plans to become pregnant[/size]

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<li dir="ltr" style="list-style-type: disc; font-size: 11pt; font-family: Arial,sans-serif; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre;">
<p dir="ltr" style="line-height: 1.38; margin-top: 0pt; margin-bottom: 12pt;">[size= 11pt; font-family: Arial,sans-serif; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap]Breastfeeding[/size]

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<p dir="ltr" style="line-height: 1.38; margin-top: 12pt; margin-bottom: 12pt;">[size= 11pt; font-family: Arial,sans-serif; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap]Older adults may be more vulnerable to confusion, balance problems, falls, and other adverse effects from sedative medicines. MedlinePlus advises older adults to discuss the risks and benefits of zolpidem carefully with their healthcare professional.[/size]

<h1 dir="ltr" style="line-height: 1.38; margin-top: 24pt; margin-bottom: 6pt;">[size= 23pt; font-family: Arial,sans-serif; color: #000000; background-color: transparent; font-weight: bold; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap]Ambien During Pregnancy and Breastfeeding[/size]</h1>
<p dir="ltr" style="line-height: 1.38; margin-top: 12pt; margin-bottom: 12pt;">[size= 11pt; font-family: Arial,sans-serif; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap]Patients who are pregnant, planning pregnancy, or breastfeeding should discuss zolpidem with their healthcare professional before using it. The clinician can consider the individual's sleep problem, medical circumstances, and potential medication risks when deciding whether treatment is appropriate.[/size]

<p dir="ltr" style="line-height: 1.38; margin-top: 12pt; margin-bottom: 12pt;">[size= 11pt; font-family: Arial,sans-serif; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap]Do not start, stop, or change prescription treatment during pregnancy without professional guidance.[/size]

<h1 dir="ltr" style="line-height: 1.38; margin-top: 24pt; margin-bottom: 6pt;">[size= 23pt; font-family: Arial,sans-serif; color: #000000; background-color: transparent; font-weight: bold; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap]What to Do If Ambien Does Not Improve Sleep[/size]</h1>
<p dir="ltr" style="line-height: 1.38; margin-top: 12pt; margin-bottom: 12pt;">[size= 11pt; font-family: Arial,sans-serif; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap]Zolpidem is not intended to address every possible cause of insomnia. If sleep problems continue or become worse, the patient should speak with the prescribing healthcare professional. MedlinePlus advises contacting a doctor when sleep problems do not improve within the expected treatment period or worsen during treatment.[/size]

<p dir="ltr" style="line-height: 1.38; margin-top: 12pt; margin-bottom: 12pt;">[size= 11pt; font-family: Arial,sans-serif; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap]Persistent insomnia may require evaluation for other causes, such as anxiety, depression, chronic pain, medication effects, sleep apnea, restless legs syndrome, inconsistent sleep schedules, or other medical conditions.[/size]

<h1 dir="ltr" style="line-height: 1.38; margin-top: 24pt; margin-bottom: 6pt;">[size= 23pt; font-family: Arial,sans-serif; color: #000000; background-color: transparent; font-weight: bold; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap]Non-Medicine Treatment for Insomnia[/size]</h1>
<p dir="ltr" style="line-height: 1.38; margin-top: 12pt; margin-bottom: 12pt;">[size= 11pt; font-family: Arial,sans-serif; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap]Medication can be only one part of an insomnia treatment plan. Behavioral and lifestyle approaches can be useful, especially when sleep problems persist.[/size]

<p dir="ltr" style="line-height: 1.38; margin-top: 12pt; margin-bottom: 12pt;">[size= 11pt; font-family: Arial,sans-serif; color: #000000; background-color: transparent; font-weight: bold; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap]Cognitive behavioral therapy for insomnia (CBT-I)[/size][size= 11pt; font-fam