<h1 dir="ltr" style="line-height: 2.16; background-color: #ffffff; margin-top: 12pt; margin-bottom: 0pt; padding: 0pt 0pt 8pt 0pt;">[size= 33pt; font-family: Merriweather,serif; color: #0000ff; background-color: #f4cccc; font-weight: bold; font-style: italic; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap]CLICK HERE TO BUY NOW[/size]</h1>
<h1 dir="ltr" style="line-height: 1.656; background-color: #ffffff; margin-top: 0pt; margin-bottom: 0pt; padding: 4pt 0pt 0pt 0pt;"> </h1>
<p dir="ltr" style="line-height: 1.38; margin-top: 12pt; margin-bottom: 12pt;">[size= 11pt; font-family: Arial,sans-serif; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap]Soma is a prescription opioid pain reliever used to manage severe pain when other treatments may not provide adequate relief. It works primarily by changing how the brain and nervous system perceive and respond to pain.[/size]

<p dir="ltr" style="line-height: 1.38; margin-top: 12pt; margin-bottom: 12pt;">[size= 11pt; font-family: Arial,sans-serif; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap]Although Soma can provide substantial pain relief, it also carries important risks. These include [/size][size= 11pt; font-family: Arial,sans-serif; color: #000000; background-color: transparent; font-weight: bold; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap]sleepiness, constipation, physical dependence, opioid use disorder, respiratory depression, and potentially fatal overdose[/size][size= 11pt; font-family: Arial,sans-serif; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap]. The risk can increase when Soma is taken inappropriately or combined with alcohol, sedatives, or certain other medications.[/size]

<p dir="ltr" style="line-height: 1.38; margin-top: 12pt; margin-bottom: 12pt;">[size= 11pt; font-family: Arial,sans-serif; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap]For that reason, Soma should be used only as prescribed and monitored by a qualified healthcare professional.[/size]

<h2 dir="ltr" style="line-height: 1.38; margin-top: 18pt; margin-bottom: 4pt;">[size= 17pt; font-family: Arial,sans-serif; color: #000000; background-color: transparent; font-weight: bold; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap]What Is Soma?[/size]</h2>
<p dir="ltr" style="line-height: 1.38; margin-top: 12pt; margin-bottom: 12pt;">[size= 11pt; font-family: Arial,sans-serif; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap]Soma is a [/size][size= 11pt; font-family: Arial,sans-serif; color: #000000; background-color: transparent; font-weight: bold; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap]prescription opioid analgesic[/size][size= 11pt; font-family: Arial,sans-serif; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap], sometimes called a narcotic pain reliever. It is prescribed for severe pain and is available in immediate-release and extended-release formulations, as well as in some combination products.[/size]

<p dir="ltr" style="line-height: 1.38; margin-top: 12pt; margin-bottom: 12pt;">[size= 11pt; font-family: Arial,sans-serif; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap]Soma does not eliminate the underlying cause of pain. Instead, it changes the way the central nervous system responds to painful signals.[/size]

<p dir="ltr" style="line-height: 1.38; margin-top: 12pt; margin-bottom: 12pt;">[size= 11pt; font-family: Arial,sans-serif; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap]Because opioids can produce physical dependence and other serious harms, clinicians generally consider whether non-opioid treatments may be appropriate before initiating opioid therapy. The CDC notes that non-opioid treatments can be at least as effective as opioids for many common types of acute pain.[/size]

<h2 dir="ltr" style="line-height: 1.38; margin-top: 18pt; margin-bottom: 4pt;">[size= 17pt; font-family: Arial,sans-serif; color: #000000; background-color: transparent; font-weight: bold; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap]Key Takeaways[/size]</h2>
<ul style="margin-top: 0; margin-bottom: 0; padding-inline-start: 48px;">
<li dir="ltr" style="list-style-type: disc; font-size: 11pt; font-family: Arial,sans-serif; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre;">
<p dir="ltr" style="line-height: 1.38; margin-top: 12pt; margin-bottom: 0pt;">[size= 11pt; font-family: Arial,sans-serif; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap]Soma is a [/size][size= 11pt; font-family: Arial,sans-serif; color: #000000; background-color: transparent; font-weight: bold; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap]prescription opioid used for severe pain[/size][size= 11pt; font-family: Arial,sans-serif; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap].[/size]

</li>
<li dir="ltr" style="list-style-type: disc; font-size: 11pt; font-family: Arial,sans-serif; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre;">
<p dir="ltr" style="line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;">[size= 11pt; font-family: Arial,sans-serif; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap]It is available in immediate-release and extended-release forms.[/size]

</li>
<li dir="ltr" style="list-style-type: disc; font-size: 11pt; font-family: Arial,sans-serif; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre;">
<p dir="ltr" style="line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;">[size= 11pt; font-family: Arial,sans-serif; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap]Some products combine Soma with another pain-relieving ingredient.[/size]

</li>
<li dir="ltr" style="list-style-type: disc; font-size: 11pt; font-family: Arial,sans-serif; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre;">
<p dir="ltr" style="line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;">[size= 11pt; font-family: Arial,sans-serif; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap]Soma can cause [/size][size= 11pt; font-family: Arial,sans-serif; color: #000000; background-color: transparent; font-weight: bold; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap]drowsiness, nausea, constipation, and dizziness[/size][size= 11pt; font-family: Arial,sans-serif; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap].[/size]

</li>
<li dir="ltr" style="list-style-type: disc; font-size: 11pt; font-family: Arial,sans-serif; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre;">
<p dir="ltr" style="line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;">[size= 11pt; font-family: Arial,sans-serif; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap]A major safety concern is [/size][size= 11pt; font-family: Arial,sans-serif; color: #000000; background-color: transparent; font-weight: bold; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap]slow or difficult breathing[/size][size= 11pt; font-family: Arial,sans-serif; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap], particularly when treatment begins or the dose is increased.[/size]

</li>
<li dir="ltr" style="list-style-type: disc; font-size: 11pt; font-family: Arial,sans-serif; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre;">
<p dir="ltr" style="line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;">[size= 11pt; font-family: Arial,sans-serif; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap]Combining Soma with alcohol or certain sedating medicines can cause dangerous sedation and respiratory depression.[/size]

</li>
<li dir="ltr" style="list-style-type: disc; font-size: 11pt; font-family: Arial,sans-serif; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre;">
<p dir="ltr" style="line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;">[size= 11pt; font-family: Arial,sans-serif; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap]Repeated use can lead to [/size][size= 11pt; font-family: Arial,sans-serif; color: #000000; background-color: transparent; font-weight: bold; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap]tolerance and physical dependence[/size][size= 11pt; font-family: Arial,sans-serif; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap], and some people develop opioid use disorder.[/size]

</li>
<li dir="ltr" style="list-style-type: disc; font-size: 11pt; font-family: Arial,sans-serif; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre;">
<p dir="ltr" style="line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;">[size= 11pt; font-family: Arial,sans-serif; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap]Extended-release Soma products must be handled exactly as directed; crushing or otherwise altering certain formulations can result in rapid release of a potentially dangerous amount of medicine.[/size]

</li>
<li dir="ltr" style="list-style-type: disc; font-size: 11pt; font-family: Arial,sans-serif; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre;">
<p dir="ltr" style="line-height: 1.38; margin-top: 0pt; margin-bottom: 12pt;">[size= 11pt; font-family: Arial,sans-serif; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap]Naloxone or another opioid-overdose reversal medication may be appropriate for people taking prescription opioids, depending on individual risk.[/size]

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</ul>
<h2 dir="ltr" style="line-height: 1.38; margin-top: 18pt; margin-bottom: 4pt;">[size= 17pt; font-family: Arial,sans-serif; color: #000000; background-color: transparent; font-weight: bold; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap]What Is Soma Used For?[/size]</h2>
<p dir="ltr" style="line-height: 1.38; margin-top: 12pt; margin-bottom: 12pt;">[size= 11pt; font-family: Arial,sans-serif; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap]Soma is primarily prescribed to relieve [/size][size= 11pt; font-family: Arial,sans-serif; color: #000000; background-color: transparent; font-weight: bold; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap]severe pain[/size][size= 11pt; font-family: Arial,sans-serif; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap]. Depending on the formulation and clinical circumstances, it may be used for significant pain associated with surgery, serious injury, or certain medical conditions.[/size]

<p dir="ltr" style="line-height: 1.38; margin-top: 12pt; margin-bottom: 12pt;">[size= 11pt; font-family: Arial,sans-serif; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap]The decision to prescribe an opioid depends on the cause and severity of pain, expected duration of treatment, previous treatments, medical history, other medicines, and the individual's risk factors.[/size]

<p dir="ltr" style="line-height: 1.38; margin-top: 12pt; margin-bottom: 12pt;">[size= 11pt; font-family: Arial,sans-serif; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap]Soma is not automatically the best choice for every type of pain. For many forms of acute pain, non-opioid medicines and non-drug treatments can provide effective relief without exposing a person to opioid-related risks.[/size]

<h2 dir="ltr" style="line-height: 1.38; margin-top: 18pt; margin-bottom: 4pt;">[size= 17pt; font-family: Arial,sans-serif; color: #000000; background-color: transparent; font-weight: bold; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap]How Does Soma Work?[/size]</h2>
<p dir="ltr" style="line-height: 1.38; margin-top: 12pt; margin-bottom: 12pt;">[size= 11pt; font-family: Arial,sans-serif; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap]Soma belongs to the [/size][size= 11pt; font-family: Arial,sans-serif; color: #000000; background-color: transparent; font-weight: bold; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap]opioid analgesic[/size][size= 11pt; font-family: Arial,sans-serif; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap] class.[/size]

<p dir="ltr" style="line-height: 1.38; margin-top: 12pt; margin-bottom: 12pt;">[size= 11pt; font-family: Arial,sans-serif; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap]Pain signals travel through nerves to the spinal cord and brain, where they are interpreted as pain. Soma binds to opioid receptors in the nervous system and changes the transmission and perception of those signals.[/size]

<p dir="ltr" style="line-height: 1.38; margin-top: 12pt; margin-bottom: 12pt;">[size= 11pt; font-family: Arial,sans-serif; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap]This produces analgesia, but opioid receptors are also involved in breathing, alertness, gastrointestinal activity, and reward pathways. Consequently, the same drug effects that reduce pain can also produce sleepiness, constipation, respiratory depression, and dependence.[/size]

<h2 dir="ltr" style="line-height: 1.38; margin-top: 18pt; margin-bottom: 4pt;">[size= 17pt; font-family: Arial,sans-serif; color: #000000; background-color: transparent; font-weight: bold; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap]Soma Forms and Products[/size]</h2>
<p dir="ltr" style="line-height: 1.38; margin-top: 12pt; margin-bottom: 12pt;">[size= 11pt; font-family: Arial,sans-serif; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap]Soma is available in several oral formulations, including:[/size]

<ul style="margin-top: 0; margin-bottom: 0; padding-inline-start: 48px;">
<li dir="ltr" style="list-style-type: disc; font-size: 11pt; font-family: Arial,sans-serif; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre;">
<p dir="ltr" style="line-height: 1.38; margin-top: 12pt; margin-bottom: 0pt;">[size= 11pt; font-family: Arial,sans-serif; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap]Immediate-release tablets[/size]

</li>
<li dir="ltr" style="list-style-type: disc; font-size: 11pt; font-family: Arial,sans-serif; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre;">
<p dir="ltr" style="line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;">[size= 11pt; font-family: Arial,sans-serif; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap]Capsules[/size]

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<li dir="ltr" style="list-style-type: disc; font-size: 11pt; font-family: Arial,sans-serif; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre;">
<p dir="ltr" style="line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;">[size= 11pt; font-family: Arial,sans-serif; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap]Oral solution[/size]

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<li dir="ltr" style="list-style-type: disc; font-size: 11pt; font-family: Arial,sans-serif; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre;">
<p dir="ltr" style="line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;">[size= 11pt; font-family: Arial,sans-serif; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap]Extended-release tablets[/size]

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<li dir="ltr" style="list-style-type: disc; font-size: 11pt; font-family: Arial,sans-serif; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre;">
<p dir="ltr" style="line-height: 1.38; margin-top: 0pt; margin-bottom: 12pt;">[size= 11pt; font-family: Arial,sans-serif; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap]Extended-release capsules[/size]

</li>
</ul>
<p dir="ltr" style="line-height: 1.38; margin-top: 12pt; margin-bottom: 12pt;">[size= 11pt; font-family: Arial,sans-serif; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap]It is also available in certain combination medicines containing another active ingredient.[/size]

<p dir="ltr" style="line-height: 1.38; margin-top: 12pt; margin-bottom: 12pt;">[size= 11pt; font-family: Arial,sans-serif; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap]Examples of brand names associated with Soma products include [/size][size= 11pt; font-family: Arial,sans-serif; color: #000000; background-color: transparent; font-weight: bold; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap]OxyContin, Roxicodone, Roxybond, and Xtampza ER[/size][size= 11pt; font-family: Arial,sans-serif; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap]. Some older branded products may no longer be marketed, while generic alternatives can remain available.[/size]

<h3 dir="ltr" style="line-height: 1.38; margin-top: 14pt; margin-bottom: 4pt;">[size= 13pt; font-family: Arial,sans-serif; color: #000000; background-color: transparent; font-weight: bold; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap]Soma Combination Medicines[/size]</h3>
<p dir="ltr" style="line-height: 1.38; margin-top: 12pt; margin-bottom: 12pt;">[size= 11pt; font-family: Arial,sans-serif; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap]Some products contain Soma together with another medicine. Examples include combinations with acetaminophen, aspirin, ibuprofen, naloxone, or other ingredients.[/size]

<p dir="ltr" style="line-height: 1.38; margin-top: 12pt; margin-bottom: 12pt;">[size= 11pt; font-family: Arial,sans-serif; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap]This distinction matters because the additional ingredient can introduce its own risks and restrictions.[/size]

<p dir="ltr" style="line-height: 1.38; margin-top: 12pt; margin-bottom: 12pt;">[size= 11pt; font-family: Arial,sans-serif; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap]For example, taking an Soma product containing acetaminophen together with other acetaminophen-containing medicines can unintentionally increase total acetaminophen exposure.[/size]

<p dir="ltr" style="line-height: 1.38; margin-top: 12pt; margin-bottom: 12pt;">[size= 11pt; font-family: Arial,sans-serif; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap]Always identify [/size][size= 11pt; font-family: Arial,sans-serif; color: #000000; background-color: transparent; font-weight: bold; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap]all active ingredients[/size][size= 11pt; font-family: Arial,sans-serif; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap] in a combination product before taking another pain medicine.[/size]

<h2 dir="ltr" style="line-height: 1.38; margin-top: 18pt; margin-bottom: 4pt;">[size= 17pt; font-family: Arial,sans-serif; color: #000000; background-color: transparent; font-weight: bold; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap]Immediate-Release vs. Extended-Release Soma[/size]</h2>
<p dir="ltr" style="line-height: 1.38; margin-top: 12pt; margin-bottom: 12pt;">[size= 11pt; font-family: Arial,sans-serif; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap]The two broad formulation types have different purposes.[/size]

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<td style="vertical-align: top; padding: 5pt 5pt 5pt 5pt; overflow: hidden; overflow-wrap: break-word;">
<p dir="ltr" style="line-height: 1.38; text-align: center; margin-top: 0pt; margin-bottom: 0pt;">[size= 11pt; font-family: Arial,sans-serif; color: #000000; background-color: transparent; font-weight: bold; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap]Feature[/size]

</td>
<td style="vertical-align: top; padding: 5pt 5pt 5pt 5pt; overflow: hidden; overflow-wrap: break-word;">
<p dir="ltr" style="line-height: 1.38; text-align: center; margin-top: 0pt; margin-bottom: 0pt;">[size= 11pt; font-family: Arial,sans-serif; color: #000000; background-color: transparent; font-weight: bold; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap]Immediate-release Soma[/size]

</td>
<td style="vertical-align: top; padding: 5pt 5pt 5pt 5pt; overflow: hidden; overflow-wrap: break-word;">
<p dir="ltr" style="line-height: 1.38; text-align: center; margin-top: 0pt; margin-bottom: 0pt;">[size= 11pt; font-family: Arial,sans-serif; color: #000000; background-color: transparent; font-weight: bold; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap]Extended-release Soma[/size]

</td>
</tr>
<tr style="height: 39.25pt;">
<td style="vertical-align: top; padding: 5pt 5pt 5pt 5pt; overflow: hidden; overflow-wrap: break-word;">
<p dir="ltr" style="line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;">[size= 11pt; font-family: Arial,sans-serif; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap]Release[/size]

</td>
<td style="vertical-align: top; padding: 5pt 5pt 5pt 5pt; overflow: hidden; overflow-wrap: break-word;">
<p dir="ltr" style="line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;">[size= 11pt; font-family: Arial,sans-serif; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap]Releases medicine more quickly[/size]

</td>
<td style="vertical-align: top; padding: 5pt 5pt 5pt 5pt; overflow: hidden; overflow-wrap: break-word;">
<p dir="ltr" style="line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;">[size= 11pt; font-family: Arial,sans-serif; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap]Releases medicine gradually[/size]

</td>
</tr>
<tr style="height: 53.5pt;">
<td style="vertical-align: top; padding: 5pt 5pt 5pt 5pt; overflow: hidden; overflow-wrap: break-word;">
<p dir="ltr" style="line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;">[size= 11pt; font-family: Arial,sans-serif; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap]General purpose[/size]

</td>
<td style="vertical-align: top; padding: 5pt 5pt 5pt 5pt; overflow: hidden; overflow-wrap: break-word;">
<p dir="ltr" style="line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;">[size= 11pt; font-family: Arial,sans-serif; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap]Often used for pain requiring shorter-acting treatment[/size]

</td>
<td style="vertical-align: top; padding: 5pt 5pt 5pt 5pt; overflow: hidden; overflow-wrap: break-word;">
<p dir="ltr" style="line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;">[size= 11pt; font-family: Arial,sans-serif; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap]Intended for ongoing, severe pain requiring around-the-clock opioid treatment in appropriate patients[/size]

</td>
</tr>
<tr style="height: 39.25pt;">
<td style="vertical-align: top; padding: 5pt 5pt 5pt 5pt; overflow: hidden; overflow-wrap: break-word;">
<p dir="ltr" style="line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;">[size= 11pt; font-family: Arial,sans-serif; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap]Frequency[/size]

</td>
<td style="vertical-align: top; padding: 5pt 5pt 5pt 5pt; overflow: hidden; overflow-wrap: break-word;">
<p dir="ltr" style="line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;">[size= 11pt; font-family: Arial,sans-serif; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap]Depends on the prescribed product[/size]

</td>
<td style="vertical-align: top; padding: 5pt 5pt 5pt 5pt; overflow: hidden; overflow-wrap: break-word;">
<p dir="ltr" style="line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;">[size= 11pt; font-family: Arial,sans-serif; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap]Designed for longer-lasting effect[/size]

</td>
</tr>
<tr style="height: 39.25pt;">
<td style="vertical-align: top; padding: 5pt 5pt 5pt 5pt; overflow: hidden; overflow-wrap: break-word;">
<p dir="ltr" style="line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;">[size= 11pt; font-family: Arial,sans-serif; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap]Important safety issue[/size]

</td>
<td style="vertical-align: top; padding: 5pt 5pt 5pt 5pt; overflow: hidden; overflow-wrap: break-word;">
<p dir="ltr" style="line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;">[size= 11pt; font-family: Arial,sans-serif; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap]Taking doses too frequently can increase overdose risk[/size]

</td>
<td style="vertical-align: top; padding: 5pt 5pt 5pt 5pt; overflow: hidden; overflow-wrap: break-word;">
<p dir="ltr" style="line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;">[size= 11pt; font-family: Arial,sans-serif; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap]Some products can release too much medicine if crushed, chewed, or otherwise altered[/size]

</td>
</tr>
</tbody>
</table>
</div>
<p dir="ltr" style="line-height: 1.38; margin-top: 12pt; margin-bottom: 12pt;">[size= 11pt; font-family: Arial,sans-serif; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap]Extended-release products require particular care. Certain tablets must be swallowed whole because crushing, chewing, breaking, or dissolving them can cause too much Soma to be released at once.[/size]

<h2 dir="ltr" style="line-height: 1.38; margin-top: 18pt; margin-bottom: 4pt;">[size= 17pt; font-family: Arial,sans-serif; color: #000000; background-color: transparent; font-weight: bold; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap]Is Soma Effective for Pain?[/size]</h2>
<p dir="ltr" style="line-height: 1.38; margin-top: 12pt; margin-bottom: 12pt;">[size= 11pt; font-family: Arial,sans-serif; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap]Soma can be effective at reducing severe pain. However, effectiveness must be considered alongside potential harms.[/size]

<p dir="ltr" style="line-height: 1.38; margin-top: 12pt; margin-bottom: 12pt;">[size= 11pt; font-family: Arial,sans-serif; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap]Opioids are not necessarily more effective than non-opioid options for every painful condition. The CDC recommends considering non-opioid pharmacologic and non-pharmacologic therapies when appropriate and using opioids when expected benefits for pain and function are anticipated to outweigh risks.[/size]

<p dir="ltr" style="line-height: 1.38; margin-top: 12pt; margin-bottom: 12pt;">[size= 11pt; font-family: Arial,sans-serif; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap]The appropriate treatment therefore depends on:[/size]

<ul style="margin-top: 0; margin-bottom: 0; padding-inline-start: 48px;">
<li dir="ltr" style="list-style-type: disc; font-size: 11pt; font-family: Arial,sans-serif; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre;">
<p dir="ltr" style="line-height: 1.38; margin-top: 12pt; margin-bottom: 0pt;">[size= 11pt; font-family: Arial,sans-serif; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap]The cause of pain[/size]

</li>
<li dir="ltr" style="list-style-type: disc; font-size: 11pt; font-family: Arial,sans-serif; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre;">
<p dir="ltr" style="line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;">[size= 11pt; font-family: Arial,sans-serif; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap]Pain severity[/size]

</li>
<li dir="ltr" style="list-style-type: disc; font-size: 11pt; font-family: Arial,sans-serif; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre;">
<p dir="ltr" style="line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;">[size= 11pt; font-family: Arial,sans-serif; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap]Expected duration of pain[/size]

</li>
<li dir="ltr" style="list-style-type: disc; font-size: 11pt; font-family: Arial,sans-serif; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre;">
<p dir="ltr" style="line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;">[size= 11pt; font-family: Arial,sans-serif; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap]Previous treatments[/size]

</li>
<li dir="ltr" style="list-style-type: disc; font-size: 11pt; font-family: Arial,sans-serif; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre;">
<p dir="ltr" style="line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;">[size= 11pt; font-family: Arial,sans-serif; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap]Other medical conditions[/size]

</li>
<li dir="ltr" style="list-style-type: disc; font-size: 11pt; font-family: Arial,sans-serif; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre;">
<p dir="ltr" style="line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;">[size= 11pt; font-family: Arial,sans-serif; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap]Current medicines[/size]

</li>
<li dir="ltr" style="list-style-type: disc; font-size: 11pt; font-family: Arial,sans-serif; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre;">
<p dir="ltr" style="line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;">[size= 11pt; font-family: Arial,sans-serif; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap]Risk of opioid-related complications[/size]

</li>
<li dir="ltr" style="list-style-type: disc; font-size: 11pt; font-family: Arial,sans-serif; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre;">
<p dir="ltr" style="line-height: 1.38; margin-top: 0pt; margin-bottom: 12pt;">[size= 11pt; font-family: Arial,sans-serif; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap]The person's goals and preferences[/size]

</li>
</ul>
<h2 dir="ltr" style="line-height: 1.38; margin-top: 18pt; margin-bottom: 4pt;">[size= 17pt; font-family: Arial,sans-serif; color: #000000; background-color: transparent; font-weight: bold; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap]Common Side Effects of Soma[/size]</h2>
<p dir="ltr" style="line-height: 1.38; margin-top: 12pt; margin-bottom: 12pt;">[size= 11pt; font-family: Arial,sans-serif; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap]Common side effects may include:[/size]

<ul style="margin-top: 0; margin-bottom: 0; padding-inline-start: 48px;">
<li dir="ltr" style="list-style-type: disc; font-size: 11pt; font-family: Arial,sans-serif; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre;">
<p dir="ltr" style="line-height: 1.38; margin-top: 12pt; margin-bottom: 0pt;">[size= 11pt; font-family: Arial,sans-serif; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap]Nausea[/size]

</li>
<li dir="ltr" style="list-style-type: disc; font-size: 11pt; font-family: Arial,sans-serif; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre;">
<p dir="ltr" style="line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;">[size= 11pt; font-family: Arial,sans-serif; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap]Vomiting[/size]

</li>
<li dir="ltr" style="list-style-type: disc; font-size: 11pt; font-family: Arial,sans-serif; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre;">
<p dir="ltr" style="line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;">[size= 11pt; font-family: Arial,sans-serif; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap]Constipation[/size]

</li>
<li dir="ltr" style="list-style-type: disc; font-size: 11pt; font-family: Arial,sans-serif; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre;">
<p dir="ltr" style="line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;">[size= 11pt; font-family: Arial,sans-serif; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap]Drowsiness[/size]

</li>
<li dir="ltr" style="list-style-type: disc; font-size: 11pt; font-family: Arial,sans-serif; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre;">
<p dir="ltr" style="line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;">[size= 11pt; font-family: Arial,sans-serif; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap]Tiredness or weakness[/size]

</li>
<li dir="ltr" style="list-style-type: disc; font-size: 11pt; font-family: Arial,sans-serif; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre;">
<p dir="ltr" style="line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;">[size= 11pt; font-family: Arial,sans-serif; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap]Dizziness[/size]

</li>
<li dir="ltr" style="list-style-type: disc; font-size: 11pt; font-family: Arial,sans-serif; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre;">
<p dir="ltr" style="line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;">[size= 11pt; font-family: Arial,sans-serif; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap]Headache[/size]

</li>
<li dir="ltr" style="list-style-type: disc; font-size: 11pt; font-family: Arial,sans-serif; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre;">
<p dir="ltr" style="line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;">[size= 11pt; font-family: Arial,sans-serif; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap]Difficulty sleeping[/size]

</li>
<li dir="ltr" style="list-style-type: disc; font-size: 11pt; font-family: Arial,sans-serif; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre;">
<p dir="ltr" style="line-height: 1.38; margin-top: 0pt; margin-bottom: 12pt;">[size= 11pt; font-family: Arial,sans-serif; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap]Reduced sexual desire or sexual difficulties[/size]

</li>
</ul>
<p dir="ltr" style="line-height: 1.38; margin-top: 12pt; margin-bottom: 12pt;">[size= 11pt; font-family: Arial,sans-serif; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap]Not everyone experiences these effects, and some may become less troublesome as the body adjusts. Persistent or severe symptoms should be discussed with a healthcare professional.[/size]

<h3 dir="ltr" style="line-height: 1.38; margin-top: 14pt; margin-bottom: 4pt;">[size= 13pt; font-family: Arial,sans-serif; color: #000000; background-color: transparent; font-weight: bold; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap]Constipation[/size]</h3>
<p dir="ltr" style="line-height: 1.38; margin-top: 12pt; margin-bottom: 12pt;">[size= 11pt; font-family: Arial,sans-serif; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap]Constipation is particularly common with opioid medicines because opioids slow movement through the gastrointestinal tract.[/size]

<p dir="ltr" style="line-height: 1.38; margin-top: 12pt; margin-bottom: 12pt;">[size= 11pt; font-family: Arial,sans-serif; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap]If Soma is prescribed, ask your healthcare professional about appropriate strategies for preventing or treating opioid-related constipation. Do not assume that a persistent change in bowel habits is harmless.[/size]

<h2 dir="ltr" style="line-height: 1.38; margin-top: 18pt; margin-bottom: 4pt;">[size= 17pt; font-family: Arial,sans-serif; color: #000000; background-color: transparent; font-weight: bold; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap]Serious Side Effects and Safety Risks[/size]</h2>
<h3 dir="ltr" style="line-height: 1.38; margin-top: 14pt; margin-bottom: 4pt;">[size= 13pt; font-family: Arial,sans-serif; color: #000000; background-color: transparent; font-weight: bold; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap]Respiratory Depression[/size]</h3>
<p dir="ltr" style="line-height: 1.38; margin-top: 12pt; margin-bottom: 12pt;">[size= 11pt; font-family: Arial,sans-serif; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap]One of the most important dangers of Soma is [/size][size= 11pt; font-family: Arial,sans-serif; color: #000000; background-color: transparent; font-weight: bold; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap]respiratory depression[/size][size= 11pt; font-family: Arial,sans-serif; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap], meaning breathing becomes unusually slow, shallow, or difficult.[/size]

<p dir="ltr" style="line-height: 1.38; margin-top: 12pt; margin-bottom: 12pt;">[size= 11pt; font-family: Arial,sans-serif; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap]The risk can be especially important during the first several days of treatment and after an increase in dosage.[/size]

<p dir="ltr" style="line-height: 1.38; margin-top: 12pt; margin-bottom: 12pt;">[size= 11pt; font-family: Arial,sans-serif; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap]Warning signs can include:[/size]

<ul style="margin-top: 0; margin-bottom: 0; padding-inline-start: 48px;">
<li dir="ltr" style="list-style-type: disc; font-size: 11pt; font-family: Arial,sans-serif; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre;">
<p dir="ltr" style="line-height: 1.38; margin-top: 12pt; margin-bottom: 0pt;">[size= 11pt; font-family: Arial,sans-serif; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap]Very slow or shallow breathing[/size]

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<li dir="ltr" style="list-style-type: disc; font-size: 11pt; font-family: Arial,sans-serif; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre;">
<p dir="ltr" style="line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;">[size= 11pt; font-family: Arial,sans-serif; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap]Long pauses between breaths[/size]

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<li dir="ltr" style="list-style-type: disc; font-size: 11pt; font-family: Arial,sans-serif; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre;">
<p dir="ltr" style="line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;">[size= 11pt; font-family: Arial,sans-serif; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap]Unusual snoring in someone who is difficult to wake[/size]

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<li dir="ltr" style="list-style-type: disc; font-size: 11pt; font-family: Arial,sans-serif; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre;">
<p dir="ltr" style="line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;">[size= 11pt; font-family: Arial,sans-serif; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap]Extreme sleepiness[/size]

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<p dir="ltr" style="line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;">[size= 11pt; font-family: Arial,sans-serif; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap]Difficulty waking up[/size]

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<li dir="ltr" style="list-style-type: disc; font-size: 11pt; font-family: Arial,sans-serif; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre;">
<p dir="ltr" style="line-height: 1.38; margin-top: 0pt; margin-bottom: 12pt;">[size= 11pt; font-family: Arial,sans-serif; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap]Blue or gray-colored lips or skin[/size]

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<p dir="ltr" style="line-height: 1.38; margin-top: 12pt; margin-bottom: 12pt;">[size= 11pt; font-family: Arial,sans-serif; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap]These symptoms can indicate an opioid overdose and require immediate emergency attention.[/size]

<h3 dir="ltr" style="line-height: 1.38; margin-top: 14pt; margin-bottom: 4pt;">[size= 13pt; font-family: Arial,sans-serif; color: #000000; background-color: transparent; font-weight: bold; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap]Dependence and Opioid Use Disorder[/size]</h3>
<p dir="ltr" style="line-height: 1.38; margin-top: 12pt; margin-bottom: 12pt;">[size= 11pt; font-family: Arial,sans-serif; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap]Soma can be habit-forming even when taken according to a prescription. Repeated exposure can result in physical dependence, meaning the body adapts to the medicine.[/size]

<p dir="ltr" style="line-height: 1.38; margin-top: 12pt; margin-bottom: 12pt;">[size= 11pt; font-family: Arial,sans-serif; color: #000000; background-color: transparent; font-weight: bold; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap]Physical dependence is not the same thing as opioid use disorder[/size][size= 11pt; font-family: Arial,sans-serif; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap], although dependence can occur as part of opioid use disorder.[/size]

<p dir="ltr" style="line-height: 1.38; margin-top: 12pt; margin-bottom: 12pt;">[size= 11pt; font-family: Arial,sans-serif; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap]Signs that may indicate problematic opioid use include:[/size]

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<li dir="ltr" style="list-style-type: disc; font-size: 11pt; font-family: Arial,sans-serif; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre;">
<p dir="ltr" style="line-height: 1.38; margin-top: 12pt; margin-bottom: 0pt;">[size= 11pt; font-family: Arial,sans-serif; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap]Taking the medicine in ways other than prescribed[/size]

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<li dir="ltr" style="list-style-type: disc; font-size: 11pt; font-family: Arial,sans-serif; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre;">
<p dir="ltr" style="line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;">[size= 11pt; font-family: Arial,sans-serif; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap]Repeatedly taking more than directed[/size]

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<li dir="ltr" style="list-style-type: disc; font-size: 11pt; font-family: Arial,sans-serif; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre;">
<p dir="ltr" style="line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;">[size= 11pt; font-family: Arial,sans-serif; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap]Compulsive use[/size]

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<li dir="ltr" style="list-style-type: disc; font-size: 11pt; font-family: Arial,sans-serif; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre;">
<p dir="ltr" style="line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;">[size= 11pt; font-family: Arial,sans-serif; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap]Continuing use despite significant harm[/size]

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<li dir="ltr" style="list-style-type: disc; font-size: 11pt; font-family: Arial,sans-serif; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre;">
<p dir="ltr" style="line-height: 1.38; margin-top: 0pt; margin-bottom: 0pt;">[size= 11pt; font-family: Arial,sans-serif; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decoration: none; vertical-align: baseline; white-space: pre-wrap]Spending substantial time obtaining or using opioids[/size]

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<li dir="ltr" style="list-style-type: disc; font-size: 11pt; font-family: Arial,sans-serif; color: #000000; background-color: transparent; font-weight: 400; font-style: normal; font-variant: normal; text-decorat