Mulberry trees are generally hardy but may occasionally experience issues such as powdery mildew, leaf spot, root rot, aphids, or scale insects. Prevent most problems by planting the tree in well-drained soil, avoiding excessive watering, and ensuring good airflow through regular pruning. Inspect leaves and branches periodically for pests and treat infestations with horticultural oil or insecticidal soap if needed. Maintaining proper growing conditions significantly reduces the risk of diseases and keeps the tree thriving.